Gigaohm Biological (8 March)

Gigaohm Biological (8 March)

This is an important video which fills in a missing puzzle piece that as been known since 1998 and yet they neglect to mention it.  You hear a lot about antibodies, but this is the first time I heard about mannose-binding lectin (MBL). There are 2 main parts of the immune system: The innate or complement immune system. You are born with this. The adaptive immune system.  Antibodies belong to the adaptive system and MBS to the innate or complement system.

The lectin pathway is one of three pathways by which the complement system can be activated. This pathway is initiated by the binding of mannose-binding lectin (MBL), collectin 11 (CL-K1), and ficolins (Ficolin-1, Ficolin-2, and Ficolin-3) to microbial surface oligosaccharides and acetylated residues, respectively. MBL belongs to the class of collectins in the C-type lectin superfamily, whose function appears to be pattern recognition in the first line of defense in the pre-immune host. MBL recognizes carbohydrate patterns found on the surface of a large number of pathogenic micro-organisms, including bacteria, viruses, protozoa and fungi. Binding of MBL to a micro-organism results in activation of the lectin pathway of the complement system.

Tiny Bombs in your Blood – The Complement System (8 min)

Immunity is more than the presence or absence of antibodies

Opsonization is the process of recognizing and targeting invading particles for phagocytosis. Opsonins are extracellular proteins that, when bound to substances or cells, induce phagocytes to phagocytose the substances or cells with the opsonins bound. Thus, opsonins act as tags to label things in the body that should be phagocytosed (i.e. eaten) by phagocytes (cells that specialise in phagocytosis, i.e. cellular eating). Different types of things (“targets”) can be tagged by opsonins for phagocytosis, including: pathogens (such as bacteria), cancer cells, aged cells, dead or dying cells (such as apoptotic cells), excess synapses, or protein aggregates (such as amyloid plaques). Opsonins help clear pathogens, as well as dead, dying and diseased cells.

Here follows a simplified version of what Jonathan is saying using the articles below. Sars_CoV-2 can bind MBL. Mannose-binding lectin (MBL) are long floppy sticky chains or oligomers (like polymers but shorter).  These chains do not recognize epitopes, but they identify glycosylation patterns  -repeating carbohydrate patterns making things stick together so that macrophages can clean them up so that the complement system can be called in to for them to be degraded.

Patients who were genetically deficient in Mannan Binding Lectin (MBL) became resistant to infection when MBL was transferred from healthy people. If you have susceptibility to HIV it could be because defective MBL protein they know it opsonizes influenza…and it binds to gp120 HIV so it will bind the spike protein which has gp120 HIV. So the spike protein is attracting lectin. Lectin is one of the main ways that macrophages are being activated. Dysregulated macrophages and neutrophils overload -overstimulation of lectin may be causing ADE where the antibodies block IgM and the complement system?

MBLs and Immunity–Gigaohm Biological High Resistance Low Noise Information Brief: Biology Served Fresh Daily

Starts at 4:45min 1:12min long.  The MBL section starts at approx. 50 min

Min                                          Article
50 Mannose-binding lectin in innate immunity: past, present and future
56 Enhanced Antiviral and Opsonic Activity of a Human Mannose Binding Lectin and Surfactant Protein D Chimera
57 Reconstitution of Opsonizing Activity by Infusion of Mannan-Binding Lection (MBL) to MBL-Deficient Humans
58 Impact of Mannose-Binding Lectin on Susceptibility of Infectious diseases Binds to gp120HIV
59 Mannose-binding lectin in severe acute respiratory syndrome coronavirus infection
1:04 Anti–spike IgG causes severe acute lung injury by skewing macrophage responses during acute SARS-CoV infection