Spike Protein Destroys Mitochondria

Spike Protein Destroys Mitochondria

Covid is not just “a flu” as some suggest and the vaccine is not a cure it is a toxic transfection which codes for the spike protein.  This article is part of an ongoing series about mitochondria and lipids because I have a special interest as my family carries the Fabry mutation causing  Lysosomal Storage Disorders (LSD).  Fabry disease modifies mitochondrial structure in four different organs.  Fabry disease, an X-linked genetic condition, results from alpha-galactosidase deficiency and increased accumulation of glycosphingolipids in cardiovascular tissues.  The other blogs in this series can be found here:

https://www.biblaridion.info/blog/my-big-toe/

https://www.biblaridion.info/blog/lsd-and-covid-part-1/

https://www.biblaridion.info/blog/lsd-and-covid-part-2/

So this subject is of specific interest to me. At the moment my feet are fine. No sensations or numbness, no swelling, no red toes and no stabbing pains. My hypothesis is that every-time I encounter the virus it triggers the latent Fabry (I only have an 11% loading) so my strategy is to strengthen overall immune health and particularly mitochondrial health.  I just completed a 24 hour fast (without taking any supplements but drinking percolated coffee) and feel great but I need to lose more weight.  I have been taking Lipoic Acid (ALA and RLA) , CoQ10, Niacin as well as other supplements (Skullcap, D with K2 MK7, quercetin,NAC, C and Zn and the occasional melatonin etc etc). As well as that I am making and drinking my own kefir water, kombucha, kefir milk, making natto and trying to walk every day (got 2 hours in today). I am gardening and pickling my own veg and my chooks are laying eggs.  The Powers That Be have effectively pulled the pin on bio-warfare and we need to stay as healthy as possible.

Spike Protein Destroys Mitochondria (Studies)

It seems that my coffee and fasting are really doing the trick:

Caffeine and Autophagy To Reduce Fats in Liver

Lipids

One of the comments under Walters article was particularly interesting.

Both ozone and UVB (Ultra Violet B) cause lipid peroxidation – the main difference being the amount of antioxidants and ROS produced.

Reactive oxygen species (ROS) are natural byproducts of cellular oxidative metabolism and play important roles in the modulation of cell survival, cell death, differentiation, cell signaling, and inflammation-related factor production. Mitochondria are an important source of ROS (reactive oxygen species) within most mammalian cells. This ROS production contributes to mitochondrial damage in a range of pathologies and is also important in redox signalling from the organelle to the rest of the cell

“UVB irradiation induces lipid peroxidation and reduces antioxidant enzyme activities”

“Ozone causes lipid peroxidation but little antioxidant depletion”

What conditions do we have at altitude – high UVB and low oxygen – those are the environmental conditions produced by the spike protein! Why are athletes more at risk of sudden death? – because their highly metabolic cardiac cells/mitochondria are under so much stress from both the spike protein and the exercise, they release a ton of UV (biophotons) and ROS/free radicals and blow the casket (heart). And all the medications found to be effective in covid have a great capacity to absorb UV light and therefore reduce this “Stress” eg Quercetin

“Inhibition of UVA and UVB radiation-induced lipid oxidation by quercetin”

It is this primordial REDOX balance in life/nature, between UVB and Oxygen that controls the actions of an aerobic cell – evolution has simply allowed adaptation on a multicellular scale.

This is not as fanciful as we have already seen the benefit of light on metabolic health:

Light and Life

Further Research

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Fenofibrate protects lipoproteins from lipid peroxidation: synergistic interaction with alpha-tocopherol

https://pubmed.ncbi.nlm.nih.gov/10380122/

Liothyronine (T3 thyroid hormone) seems to help upregulate mitochondrial biogenesis while decreasing Reactive Oxidative Species ROS, both in patients with mtDNA mutations and normal people. Effect of thyroid hormone on mitochondrial properties and oxidative stress in cells from patients with mtDNA defects

https://journals.physiology.org/doi/full/10.1152/ajpcell.00415.2007

Lipid oxidation that is, and is not, inhibited by vitamin E: Consideration about physiological functions of vitamin E

https://pubmed.ncbi.nlm.nih.gov/34481937/
https://www.hsph.harvard.edu/nutritionsource/vitamin-e/
============================

Side note to self:   Get some vitamin E and eat more almonds

Covid Health

Covid Health

I have called this post “covid health” because these measures are helpful in combating covid and/or the after effects of the “vaccine”. I have been making my own kombucha and am drinking one as I write this. I mixed half Kombucha with half tonic water (containing quinine) and two slices of lemon. Very cold and quite tasty. The Kombucha is made with green tea (I bought Matcha powder but also a pack the dried leaves etc in an Asian shop).  I got tired of trying to “sterilize” bottles etc so I streamlined the process and now have a method that works great.   I boil the kettle (I use spring water) and then put it in my “French Press”  which is usually used for coffee (example):

Then I add raw sugar, my tea and the hot water give it a good stir and let it stand allowing it to cool to room temp then simply push down the plunger.  I  purchased a large four liter jar with a tap at Drakes Supermarket in which I placed the SCOBY and the tea-sugar solution.

The point is that when I want a fresh bottle I run one off via the tap and place it in the fridge. Then I top up the Kombucha solution from my French Press.  The fresh bottle in the fridge last about 2-3 days by which time the large jar has fermented enough to run off another bottle.  This is easy as.   It has streamlined the process but even more importantly the constant fermentation makes it impossible for other bacteria to compete. No more kerfuffle with sterilization etc just rinse anything I use with very hot water.   Moreover, I can use the same “stock solution” (tea water and sugar) to make my water kefir which I also do now in a large jar.  The only difference is that this has no SCOBY and I add lemon and lime slices and dates and or figs. So, refreshing very healthy drinks.  A final tip…the jars need to breathe but not let dirt or bacteria in. Do not forget that gas builds up due to fermentation.  I found the easiest way was to use clingfilm and and elastic band then puncture holes with a tooth pick….then put a second layer and do the same. You could use cheesecloth but clingfilm is easier. Then place the lid loose on top so that gas can escape. After experimenting and doing the above I came across this article:

Kombucha Continuous Brewing


Have you tried Kombucha before? A 2014 study by Vina et.al (1) stated that it is shown that Kombucha Tea (KT) can efficiently act in health prophylaxis and recovery due to four main properties: detoxification, antioxidation, energising potencies, and promotion of depressed immunity. The recent experimental studies on the consumption of KT suggests that it is suitable for prevention against broad-spectrum metabolic and infective disorders. This makes KT attractive as a fermented functional beverage for health prophylaxis.

An important disclaimer is that Kombucha Tea is most effective when you make it yourself. This is because most commercial Kombucha is artificially produced and contains harmful food additives. The fermentation is longer than kefir and can take around 7 to 10 days but the good news is that we have developed a method whereby it can be produced daily. You never have to buy expensive, artificial Kombucha again.

Have you heard about the "Continuous Kombucha Fermentation Method"? You will need a larger vessel like our 5 L Lead-Free Ceramic Kombucha Jars

Kombucha Continuous Brew Method

1) Brew 1 L of Kombucha tea as per our instructions which can be found here
2) Establish the batch size for your continuous brew. We suggest 4L in our jars
3) Reserve 400ml of complete Kombucha tea and Kombucha SCOBY from step 1
4) Brew 4 L of Black tea using 4L boiling water, 8 organic tea bags and one 1 cup of organic rapadura sugar 
5) Cool tea to room temperature and fill into our 5 L Kombucha Jar
6) Add 400 ml reserved Kombucha tea and Scoby from step 3 and mix thoroughly
7) Cover Kombucha Jar with lid or cloth provided (your kombucha must breathe)
8) Leave to brew for 7 to 14 days. You can start tasting brew via spigot after day 7 and stop fermenting when your brew is tart and there is a new SCOBY formed on the surface of your brew
9) Your brew is ready to consume 
10) Now, this is when the magic happens. Spigot out 250ml to 500ml for your daily consumption or second fermentation 
11) Immediately replace the amount of kombucha taken out with 250ml or 500ml of cool brewed tea (same ratios of tea, sugar and water as per our recipe). We suggest making 1L of brewed tea and storing in the fridge to use as top up tea.

Note: You can also continuous brew Jun Kombucha using the same method.

(1) Current evidence on physiological activity and expected health effects of kombucha fermented beverage,Vīna I1, Semjonovs P, Linde R, Deniņa I. 2014

I am on a roll because my natto beans are successful as well and I took a picture of one of my garden trees and found out it was Magenta Lilly Pilly.  It is a native Australian and is edible so I fed some to the chooks and they love it.  Then I did a web search and found some recipes for jams and chutneys.   Made some yesterday boiled in water added apple cider vinegar, raw sugar, cinnamon, cloves, cardamom pods and mashed and reduced until I had a thick textured solution.  Cooled it down and placed in a jam jar. Delicious.  Very tangy.  I had some with apple pie and ice cream (yum) and also tried it with yogurt and believe it or not with cheese and crackers.  I am afraid the chooks are not going to get my berries anymore (lolz). A great discovery.

LILLY PILLY – Trying a Deliciously Crispy Fruit from Australia (lilli pilli) -Weird Fruit Explorer (11 min)

Melatonin

I had already heard good things about Melatonin and added it to my pile of supplements.  When I think I have been exposed or feel run down I take one before sleeping.  This video is very good. 

The MOST POWERFUL Antioxidant is Melatonin, NOT Glutathione (13 min)

  • 0:00 Introduction: The most important antioxidant is melatonin
  • 1:10 Leading causes of death
  • 2:42 Glutathione is not the most important antioxidant
  • 2:52 Benefits of melatonin
  • 4:00 What you don’t know about melatonin
  • 11:13 Causes of a deficiency of infrared light
  • 11:48 How to get more infrared light
  • 12:15 Check out my video on the therapeutic benefit of the sun

DATA:

https://www.ncbi.nlm.nih.gov/pmc/arti…

https://www.intechopen.com/chapters/6…

https://pubmed.ncbi.nlm.nih.gov/27500…

https://www.mdpi.com/2076-3921/9/11/1…

https://www.pharmacytimes.com/view/ro…

https://biomedicine.com/articles/2015…

https://www.melatonin-research.net/in…

https://www.sciencedirect.com/science…

This video is a summary of an important paper that blew me away. Three of the leading causes of death: • Heart disease • Cancer • Metabolic illnesses With each of these causes of death, there is some type of dysfunction that destroys the mitochondria. The essence of the problem is an excess of oxidative stress and free radical damage. Normally, the body protects against these things through its antioxidant networks. Glutathione has been considered the most important antioxidant. But, melatonin is even more powerful and effective than glutathione. Benefits of melatonin: • It’s a powerful antioxidant • It’s 2x more powerful than vitamin E • It triggers antioxidants like glutathione • It promotes sleep • It supports the immune system • It has anti-cancer benefits There are two forms of melatonin, one being subcellular melatonin, which means it’s inside the mitochondria. It’s there to help protect against oxidation and free radical damage in the mitochondria. A lack of melatonin can: • Affect your sleep • Cause inflammation • Cause you to lose your antioxidant protection in the mitochondria • Lead to chronic degenerative diseases (especially of the brain) The largest stimulus of subcellular melatonin is near-infrared light (NIR). A few things that give off NIR: • The sun • Campfires • Fire in a fireplace • Candles • Incandescent lights • Infrared sauna • Infrared lights and lasers Being outside in nature and in the sun may be just as important as eating healthy. Infrared light also protects against UV radiation. Being exposed to artificial lights (LED light and blue light) is a big cause of a deficiency of infrared light. What you can do: • Get outside in the sun • Get a therapeutic near-infrared light • Switch your lights to incandescent lights • Have more fires or use candles

 

 

 

 

 

 

LSD and Covid (Part 2)

LSD and Covid (Part 2)

LSD stands for Lysosomal Storage Disorders and the first part can be found hereThe disorder is otherwise known as Fabry disease and although the lysosome is a separate organelle it’s signalling pathways connect to the mitochondria.

The Dichotomous Role of Inflammation in the CNS: A Mitochondrial Point of View

The main causes of NLRP3 inflammasome activation in ischemic conditions are ascribable to mitochondria dysfunction, as abnormal Ca2+ influx, ROS production, mitochondrial membrane permeabilization with the consequent release of DAMPs and mtDNA, all conditions that are tightly linked one to the other (Figure 3). Within minutes, OGD affects mitochondria functions leading to a strong reduction of OXPHOS and therefore of ATP synthesis. Neurons in the infarct core fail to compensate the ATP cell request leading to a bust of the Na+/K+ ATPase pump [185,192]. This results in neuronal membrane depolarization accompanied by an extreme release of glutamate in the extracellular space finally leading to neurons loss [193]. Glutamate is an important excitatory neurotransmitter, which binds several types of receptors such as N-methyl-D-aspartate (NMDA) receptor, a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor and kainate receptor [194]. Although these receptors originally were thought to be exclusive to neurons, several studies revealed their functional expression also on glial cells [195,196]. The excessive amount of glutamate after stroke leads to a hyperactivation of these receptors promoting a strong influx of Ca2+ into the cells [197,198,199]. Mitochondria are the crucial players in regulating cytosolic Ca2+ levels [200], thus the massive accumulation of cytosolic Ca2+ results into the activation of the mitochondria calcium uniporter (MCU) leading to mitochondrial depolarization, which in turn drives NLRP3 inflammasome activation and the consequently IL-1β release [201]. Consistently, it has been found that in response to the activation of NMDA receptors, MCU overexpression increases mitochondrial Ca2+ levels and provokes mitochondrial membrane depolarization. Inversely, genetic knockdown of MCU reduces the NMDA-induced increase in mitochondrial Ca2+ followed by lower levels of mitochondrial depolarization [202]. In line with these findings, in focal cerebral ischemia rat models, the early stages of cerebral ischemia are characterized by an upregulation of the mitochondrial calcium uptake 1 (MICU1) a crucial regulator of MCU [203]. Interestingly this occurs in the acute phase of IS right when the inflammatory response takes place [204,205,206]. To corroborate the role of Ca2+ in mitochondria dysfunction-induced inflammation, it has been shown that NLRP3 inflammasome activation is reduced following the inhibition of extracellular Ca2+ entry or the depletion of Ca2+ stores in the ER [207]. Albeit K+ efflux, a common NLRP3 inducer [208], has been proposed to be upstream of the Ca2+-induced NLRP3 inflammasome activation, thus indicating that high levels of extracellular K+ abolish NLRP3 activation [209], the crucial contribution of mitochondrial Ca2+ overload in sustaining inflammasome activation following IS and IR is not excluded.

I found this infomercial  promoting a supplement for nerve regeneration and thought it was very good so I cut it into segments and placed the links in the tweets. I was already using N-acetylcysteine (NAC) and had ordered Niacin and α-lipoic acid (A-ALA) and R-lipoic acid (R-ALA) which I have just started taking.  The one thing that seems to work across all the mitochondrial diseases is  Co-enzyme 10 (CoQ10) which I just bought today.

 

This Review (see page 15) more or less confirms what the infomercial said. These are the supplements mentioned (some are still being trialed).

Co-enzyme 10 (CoQ10)
CoQ10 analogue, idebenone
α-tocopherol
N-acetylcysteine (NAC)
α-lipoic acid (A-ALA)
R-lipoic acid (R-ALA)
Genistein, a natural isoflavone
Trehalose
synthetic quinone, EPI-743
Thiamine (vitamin B1)
Elamipretide is an aromatic cationic tetrapeptide

Some of the synthetics (EP-743) mentioned above:

https://www.thelilyfoundation.org.uk/get-informed/questions-answers/52/

https://www.scielo.br/j/jiems/a/dYFjkzQr577HyF87nJwBTMM/?lang=en

Many of these compounds can be found in natural food. Trehalose is found in Mushrooms, yeast, honey, and shellfish all contain trehalose but their combined dietary contribution is low in comparison to added sugars in processed foods. They have started adding it to food which causes other problems. The other compounds increased the reporter activity of GAL4-PGC-1β: Genistein, daidzein, and resveratrols stimulate PGC-1β-mediated gene expression. They can be found in high soy products dark chocolate and red wine. Let food be your medicine.

Your web browser doesn’t have a PDF Plug-in. Click to download Covid articles

Conclusion

The way forward is eating healthy and walking more and experimenting with the different supplements that boost mitochondrial health.  Intermittent fasting is also good. Meditation and positive thinking. Everything is in the hands of the Almighty and remember this…. your ancestors whose defects you inherited walked  this earth for generations.  They lived, built homes, had children and died.  We  are more than a collection of genes and our destiny through grace is eternal life.

 

LSD and Covid (Part 1)

LSD and Covid (Part 1)

This is my personal health detective story (not a story about dropping acid and psychedelic experiences while combating covid…lolz).  Although this investigation is primarily for my own benefit and that of my family it has wider implications.  LSD in this investigation stands for Lysosomal Storage Disorders.   A lysosome has three main functions: the breakdown/digestion of macromolecules (carbohydrates, lipids, proteins, and nucleic acids), cell membrane repairs, and responses against foreign substances such as bacteria, viruses and other antigens.  Now the Lysosome  and the Mitochondria (Power house of the cell talk to each other.  Sometimes, they tell each other jokes and swap rude stories but usually they signal different path ways that regulate many key processes such as autophagy, proliferation, and cell death.

You may have seen in a previous post (https://www.biblaridion.info/blog/herbals-and-more/) that I was having feet problems and I found out via a blood test that I had high Calcium levels and this reminded me of something that Walter Chestnut had written (but that tweet no longer exists because Walter has been suspended from Twitter but now he is on Gab). Now it turns out that calcium is critical in regulating Mitochondrial signalling.

Fabry is not Fab

So now we come back to Lysosomes and Mitochondria talking to each other and the fact that I know that I have 12% of Fabry disease.   How do I know that?   I know because I was tested years ago because my mother suffers chronic pain and fibromyositis/fibromyalgia and the endocrinologist asked if all her children could be tested because it is a rare genetic disease and they were studying it.  Apparently I have 12% (how can you have 12% of a disease?) one sister has over 40% (she is quite sick with covid at the moment) another about 30%  and another at 0%).  To be honest I forgot all about it until my feet swelled up and started hurting.  Even then it did not occur to me until I started digging (am I thick or what?) and finally the penny dropped. If you are still reading this stick with it to the end…..because this virus will find and amplify any genetic weakness you have (and so will the vaccine). Defective lysosomal storage in Fabry disease modifies mitochondrial structure, metabolism and turnover in renal epithelial cells.

People who have Fabry disease don’t have the enzymes that break down lipids or fats. These fats collect in blood vessels and tissue, raising the risk of heart attack, stroke and kidney failure. Fabry disease is caused by mutations in the GLA gene. This gene provides instructions for making an enzyme called alpha-galactosidase A.

Lysosomal disease

Walter Chestnut got kicked off Twitter for this article ASP: SPIKE PROTEIN AMYLOIDOSIS in which he states that the spike protein is inducing fatal, systemic Amyloidosis. In his table he classifies Lysozyme as an Hereditary fibril protein within the clinical setting of familial systemic amyloidosis.  Dr Kevin McCairn has been warning for two years about neurotropic disease and amyloidosis. In fact he just discussed this paper on a live stream; Accelerated biological aging in COVID-19 patients.  The disease profile is multi-faceted and we are seeing heart attacks and strokes as well as brain disease etc. There is literally something for everyone:

This review paper by Seneff et al. (2022) summarises the current literature on mRNA and its effects on the molecular biology within human cells. The findings are shocking.

👉🏻 mRNA vaccines promote sustained synthesis of the SARS-CoV-2 spike protein.

👉🏻 The spike protein is neurotoxic, and it impairs DNA repair mechanisms.

👉🏻 Suppression of type I interferon responses results in impaired innate immunity.

👉🏻 The mRNA vaccines potentially cause increased risk to infectious diseases and cancer.

👉🏻 Codon optimization results in G-rich mRNA that has unpredictable complex effects.

The authors conclude that “billions of lives are potentially at risk, given the large number of individuals injected with the […] mRNA vaccines […]. We call on the public health institutions to demonstrate, with evidence, why the issues discussed in this paper are not relevant to public health, or to acknowledge that they are and to act accordingly.”

Conclusion

Whether you caught covid or got the “vaccine” (transfection) you are bound to come down with something. Many of us may be unaware that we have a hereditary disease.  The virus will go for any systemic weak spot. And herein lies the problem, the very diversity of symptoms and diseases makes it virtually impossible to establish causality. There will be a spectrum of responses with some people immediately harmed and others facing longer term degeneration.  It is truly the work of an evil genius…but now we know.  And you cannot hide the excess deaths and the increases in all cause mortality. The truth will out.

As for me I believe that I have the type 2 “later-onset” subtype and that it was probably triggered by Covid but it looks like it was on the cards anyway.  It seems that nothing much can be done except treat the symptoms (kidney and heart failure) or the more exotic gene therapy or more accurately Enzyme replacement therapy (ERT) is the cornerstone for treatment of Fabry disease and synthetic enzyme, produced by recombinant DNA technology, is infused intravenously.  I think I will pass on that or any other interventions like transplants.  No thank you.

However, what I have learnt is that the mitochondria make a big difference in the way that the lysosome works. Outcomes can be substantially improved if you boost mitochondrial health.  In fact, mitochondrial health makes a difference in a number of diseases.  That is what we will be looking at in part 2.

 

 

Notification: Venom

Notification: Venom

In light of the article below we remind everyone that we have stated for months that people need high Vitamin C, Nicotine (lozenges) and NAC (among the other supplements we recommended).  This will stop the  acetylcholine receptors binding to toxic epitopes and stop inflammation.

Mitochondrial Damage

Mitochondrial Damage

Kevin analyses a scientific article from the Korea Brain Research Institute where he used to work (the first article in the tweet below).  The spike is cytopathic and degrades (among other things) mitochondrial cells. The second article is about how the spike induces  mitochondrial proton/electron leak and iron overload leading to cachexia, aging, endothelial and cardiovascular pathologies.    It does not look good especially if your mitochondria are already compromised.

 

Spike Proteins of Sars-CoV-2 induce Pathological Changes in Molecular Delivery and Metabolic Function in the Brain Endothelial Cells (27 min)