{"id":21935,"date":"2021-11-23T02:14:29","date_gmt":"2021-11-23T02:14:29","guid":{"rendered":"https:\/\/www.biblaridion.info\/blog\/?p=21935"},"modified":"2021-11-23T02:14:29","modified_gmt":"2021-11-23T02:14:29","slug":"the-spike-enters-nucleus","status":"publish","type":"post","link":"https:\/\/www.biblaridion.info\/blog\/the-spike-enters-nucleus\/","title":{"rendered":"The Spike enters Nucleus"},"content":{"rendered":"\r\n<h1>The Spike enters Nucleus<\/h1>\r\n<p class=\"wp-block-paragraph\"><span class=\"style-scope yt-formatted-string\" dir=\"auto\">This video discusses a new surprise discovery (yet to be confirmed by other scientists) that the SARS-CoV-2 full length spike protein can enter human cell nuclei and interfere with the mechanics of fixing of broken DNA damage. The authors of the study propose this might have been evolved in order to prevent the genetic recombination required to produce antibody varieties to successfully attack the virus. If true, then this could have important implications for potential negative health outcomes (another if!) and might require reconfiguration of vaccine design.<\/span><\/p>\r\n<p><span class=\"style-scope yt-formatted-string\" dir=\"auto\">Discussed content: <\/span><a class=\"yt-simple-endpoint style-scope yt-formatted-string\" dir=\"auto\" spellcheck=\"false\" href=\"https:\/\/www.youtube.com\/redirect?event=video_description&amp;redir_token=QUFFLUhqbWNqbnVxR1JKeEdIdzRfWVc2SUFXelZRUVBqd3xBQ3Jtc0trbU1ONDh0MjJnNjRhSTJkcjJBTGtmM1Z3c1lWeklOS296RlRPNm5xd1BneDUxT3JTMTQzUlN5b2FFaTFQdGFvVHVSNFdqcVZKR1hwdThqZ3FDQkpsOWVjZ3BWV2xLemtsN3h3VWp4YS04SVVBLUNkSQ&amp;q=https%3A%2F%2Fwww.mdpi.com%2F1999-4915%2F13%2F10%2F2056\" target=\"_blank\" rel=\"nofollow noopener\">https:\/\/www.mdpi.com\/1999-4915\/13\/10\/&#8230;<\/a><span class=\"style-scope yt-formatted-string\" dir=\"auto\"> __________________________________________________________________ <\/span><\/p>\r\n<p><span class=\"style-scope yt-formatted-string\" dir=\"auto\">Dr. Raszek Credentials: <\/span><a class=\"yt-simple-endpoint style-scope yt-formatted-string\" dir=\"auto\" spellcheck=\"false\" href=\"https:\/\/www.youtube.com\/redirect?event=video_description&amp;redir_token=QUFFLUhqa2V6R0RRRUtZbEtTOHBqRTNYbGRCQkJIZXZjUXxBQ3Jtc0trdk9fdU9pTkhuOHpRTVY3emJSZXFqcC1YWVR1Qy1vcmxQMl9lNE16bjI3ZzJGSnpjbmdLWmxKOWNzV0k1REJQWHU2SlkxeE1icGRTaFBJUTJLbkdjMG5uZXRSby1qMENRWlZiRWxTSHpvdWVTbVoyWQ&amp;q=https%3A%2F%2Fmerogenomics.ca%2Fen%2Fabout%2F\" target=\"_blank\" rel=\"nofollow noopener\">https:\/\/merogenomics.ca\/en\/about\/<\/a><span class=\"style-scope yt-formatted-string\" dir=\"auto\"> ____________________________________________________________________<\/span><\/p>\r\n<h2 class=\"title style-scope ytd-video-primary-info-renderer\">Spike protein inside nucleus enhancing DNA damage? &#8211; COVID-19 mRNA vaccines update 18 (12 min)<\/h2>\r\n<p><iframe loading=\"lazy\" title=\"Spike protein inside nucleus enhancing DNA damage? - COVID-19 mRNA vaccines update 18\" width=\"614\" height=\"345\" src=\"https:\/\/www.youtube.com\/embed\/4Unt03UBhbU?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe><\/p>\r\n<p><span class=\"style-scope yt-formatted-string\" dir=\"auto\">Thank you for these notes made by a kind and awesome supporter:<\/span><\/p>\r\n<ul>\r\n<li><a class=\"yt-simple-endpoint style-scope yt-formatted-string\" dir=\"auto\" spellcheck=\"false\" href=\"https:\/\/www.youtube.com\/watch?v=4Unt03UBhbU&amp;t=0s\">00:00<\/a><span class=\"style-scope yt-formatted-string\" dir=\"auto\"> Dr Mikolaj Raszek, Phd from Merogenomics <\/span><\/li>\r\n<li><a class=\"yt-simple-endpoint style-scope yt-formatted-string\" dir=\"auto\" spellcheck=\"false\" href=\"https:\/\/www.youtube.com\/watch?v=4Unt03UBhbU&amp;t=9s\">00:09<\/a><span class=\"style-scope yt-formatted-string\" dir=\"auto\"> The latest widest news in Molecular Microbiology <\/span><\/li>\r\n<li><a class=\"yt-simple-endpoint style-scope yt-formatted-string\" dir=\"auto\" spellcheck=\"false\" href=\"https:\/\/www.youtube.com\/watch?v=4Unt03UBhbU&amp;t=33s\">00:33<\/a><span class=\"style-scope yt-formatted-string\" dir=\"auto\"> WHO? Swedish research shows spike protein enters nucleus in human cells (in vitro) <\/span><\/li>\r\n<li><a class=\"yt-simple-endpoint style-scope yt-formatted-string\" dir=\"auto\" spellcheck=\"false\" href=\"https:\/\/www.youtube.com\/watch?v=4Unt03UBhbU&amp;t=57s\">00:57<\/a><span class=\"style-scope yt-formatted-string\" dir=\"auto\"> this is of course, biologically verboten (*German for STRICTLY FORBIDDEN) <\/span><\/li>\r\n<li><a class=\"yt-simple-endpoint style-scope yt-formatted-string\" dir=\"auto\" spellcheck=\"false\" href=\"https:\/\/www.youtube.com\/watch?v=4Unt03UBhbU&amp;t=64s\">01:04<\/a><span class=\"style-scope yt-formatted-string\" dir=\"auto\"> WHAT? *Discovery* Spike protein inhibits proper fixing of broken DNA <\/span><\/li>\r\n<li><a class=\"yt-simple-endpoint style-scope yt-formatted-string\" dir=\"auto\" spellcheck=\"false\" href=\"https:\/\/www.youtube.com\/watch?v=4Unt03UBhbU&amp;t=78s\">01:18<\/a><span class=\"style-scope yt-formatted-string\" dir=\"auto\"> Specifics: double stranded breaks where both strands are broken <\/span><\/li>\r\n<li><a class=\"yt-simple-endpoint style-scope yt-formatted-string\" dir=\"auto\" spellcheck=\"false\" href=\"https:\/\/www.youtube.com\/watch?v=4Unt03UBhbU&amp;t=93s\">01:33<\/a><span class=\"style-scope yt-formatted-string\" dir=\"auto\"> HOW? *Mechanism 1* suspected interference with BRCA1 gene product\u2019s ability to repair DNA <\/span><\/li>\r\n<li><a class=\"yt-simple-endpoint style-scope yt-formatted-string\" dir=\"auto\" spellcheck=\"false\" href=\"https:\/\/www.youtube.com\/watch?v=4Unt03UBhbU&amp;t=108s\">01:48<\/a><span class=\"style-scope yt-formatted-string\" dir=\"auto\"> Consequence: if BRCA1 is mutated though, then you have highest predisposition for Cancer development precisely because BRCA1 gene codes for proteins that fix DNA damage when sheared in half <\/span><\/li>\r\n<li><a class=\"yt-simple-endpoint style-scope yt-formatted-string\" dir=\"auto\" spellcheck=\"false\" href=\"https:\/\/www.youtube.com\/watch?v=4Unt03UBhbU&amp;t=134s\">02:14<\/a><span class=\"style-scope yt-formatted-string\" dir=\"auto\"> Significance: Consequences are so great if true that it should be double checked, verified and reinvestigated <\/span><\/li>\r\n<li><a class=\"yt-simple-endpoint style-scope yt-formatted-string\" dir=\"auto\" spellcheck=\"false\" href=\"https:\/\/www.youtube.com\/watch?v=4Unt03UBhbU&amp;t=162s\">2:42<\/a><span class=\"style-scope yt-formatted-string\" dir=\"auto\"> Call for a lot more studies: Revalidation <\/span><\/li>\r\n<li><a class=\"yt-simple-endpoint style-scope yt-formatted-string\" dir=\"auto\" spellcheck=\"false\" href=\"https:\/\/www.youtube.com\/watch?v=4Unt03UBhbU&amp;t=171s\">2:51<\/a><span class=\"style-scope yt-formatted-string\" dir=\"auto\"> HOW? *Mechanism 2* Spike also interferes with mysterious nuclear protein 53BP1 which may serve to prevent DNA breaks from re-ligating to other DNA sources ensuring 2 chromosomes don\u2019t link together that aren\u2019t supposed to. <\/span><\/li>\r\n<li><a class=\"yt-simple-endpoint style-scope yt-formatted-string\" dir=\"auto\" spellcheck=\"false\" href=\"https:\/\/www.youtube.com\/watch?v=4Unt03UBhbU&amp;t=261s\">4:21<\/a><span class=\"style-scope yt-formatted-string\" dir=\"auto\"> HOW? *Mechanism 3* Perhaps spike in Nuclei interferes with Immune cells\u2019 mechanisms (eg.BRCA1 and 53BP1) and diversity of response to infections. <\/span><\/li>\r\n<li><a class=\"yt-simple-endpoint style-scope yt-formatted-string\" dir=\"auto\" spellcheck=\"false\" href=\"https:\/\/www.youtube.com\/watch?v=4Unt03UBhbU&amp;t=282s\">4:42<\/a><span class=\"style-scope yt-formatted-string\" dir=\"auto\"> *TAKEAWAY* What if Spike protein evolved as a mutagen for DNA \u2013 what would implications be for a vaccine that\u2019s primary focus was to produce Spike? <\/span><\/li>\r\n<li><a class=\"yt-simple-endpoint style-scope yt-formatted-string\" dir=\"auto\" spellcheck=\"false\" href=\"https:\/\/www.youtube.com\/watch?v=4Unt03UBhbU&amp;t=332s\">5:32<\/a><span class=\"style-scope yt-formatted-string\" dir=\"auto\"> CONTEXT: Recent discovery that Spikes may circulate for months on end in Exosomes to different parts of the body and in theory enter cells well after the point of vaccination as COVID-19 mRNA vaccines update 16 discussed <\/span><\/li>\r\n<li><a class=\"yt-simple-endpoint style-scope yt-formatted-string\" dir=\"auto\" spellcheck=\"false\" href=\"https:\/\/www.youtube.com\/watch?v=4Unt03UBhbU&amp;t=375s\">06:15<\/a><span class=\"style-scope yt-formatted-string\" dir=\"auto\"> CONTEXT: DNA gets 70k lesions\/day \/cell! But only 25 are double stranded shearing damages <\/span><\/li>\r\n<li><a class=\"yt-simple-endpoint style-scope yt-formatted-string\" dir=\"auto\" spellcheck=\"false\" href=\"https:\/\/www.youtube.com\/watch?v=4Unt03UBhbU&amp;t=445s\">07:25<\/a><span class=\"style-scope yt-formatted-string\" dir=\"auto\"> IMPLICATIONS: So within this context, what are the chances circulating spike proteins could enter and damage DNA and predispose to cancer? In cancer, it takes months for damage to accumulate and cause symptoms. Therefore\u2026 <\/span><\/li>\r\n<li><a class=\"yt-simple-endpoint style-scope yt-formatted-string\" dir=\"auto\" spellcheck=\"false\" href=\"https:\/\/www.youtube.com\/watch?v=4Unt03UBhbU&amp;t=465s\">7:45<\/a><span class=\"style-scope yt-formatted-string\" dir=\"auto\"> IMPLICATION: *Vaccine Safety* Are vaccines \u201cSAFE\u201d? What is vaccine \u201cSafety\u201d? Only Time can\/will tell. <\/span><\/li>\r\n<li><a class=\"yt-simple-endpoint style-scope yt-formatted-string\" dir=\"auto\" spellcheck=\"false\" href=\"https:\/\/www.youtube.com\/watch?v=4Unt03UBhbU&amp;t=487s\">8:07<\/a><span class=\"style-scope yt-formatted-string\" dir=\"auto\"> IMPLICATION: Yes, Vaccines don\u2019t produce dangerous clinical symptoms in the first few months BUT we don\u2019t know what they do in very long-term basis so can we call them safe? <\/span><\/li>\r\n<li><a class=\"yt-simple-endpoint style-scope yt-formatted-string\" dir=\"auto\" spellcheck=\"false\" href=\"https:\/\/www.youtube.com\/watch?v=4Unt03UBhbU&amp;t=514s\">8:34<\/a><span class=\"style-scope yt-formatted-string\" dir=\"auto\"> HOW? *Mechanism 4* Vaccines use FULL length of spike protein thus produces whole protein in body. Prior to vaccinations some scientists mentioned that FULL protein length of Spike protein was dangerous <\/span><\/li>\r\n<li><a class=\"yt-simple-endpoint style-scope yt-formatted-string\" dir=\"auto\" spellcheck=\"false\" href=\"https:\/\/www.youtube.com\/watch?v=4Unt03UBhbU&amp;t=556s\">9:16<\/a><span class=\"style-scope yt-formatted-string\" dir=\"auto\"> IMPLICATION: *Antibody Dependent Enhancement or ADE* could occur with use of full length of Spike protein 10:27: AUTHORS\u2019 RECOMMENDATION: Not to use full length of spike protein but only the Receptor Binding Domain or RBD portion for vaccines <\/span><a class=\"yt-simple-endpoint style-scope yt-formatted-string\" dir=\"auto\" spellcheck=\"false\" href=\"https:\/\/www.youtube.com\/watch?v=4Unt03UBhbU&amp;t=641s\">10:41<\/a><span class=\"style-scope yt-formatted-string\" dir=\"auto\"> Explanation: RBD 11:29: *TAKE AWAY* *Vaccine Safety* This shows how Vaccines are still uncharacterized on what they might be doing at the molecular level once injected in us. <\/span><\/li>\r\n<li><a class=\"yt-simple-endpoint style-scope yt-formatted-string\" dir=\"auto\" spellcheck=\"false\" href=\"https:\/\/www.youtube.com\/watch?v=4Unt03UBhbU&amp;t=712s\">11:52<\/a><span class=\"style-scope yt-formatted-string\" dir=\"auto\"> Spike protein also uncharacterized post-infection (but learning lots now). <\/span><\/li>\r\n<li><a class=\"yt-simple-endpoint style-scope yt-formatted-string\" dir=\"auto\" spellcheck=\"false\" href=\"https:\/\/www.youtube.com\/watch?v=4Unt03UBhbU&amp;t=720s\">12:00<\/a><span class=\"style-scope yt-formatted-string\" dir=\"auto\"> LIKE AND SUBSCRIBE and please *SHARE*<\/span><\/li>\r\n<\/ul>\r\n","protected":false},"excerpt":{"rendered":"<p>The Spike enters Nucleus This video discusses a new surprise discovery (yet to be confirmed by other scientists) that the SARS-CoV-2 full length spike protein can enter human cell nuclei and interfere with the mechanics of fixing of broken DNA damage. The authors of the study propose this might have been evolved in order to [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2191],"tags":[3840,6371,1968,5274],"class_list":["post-21935","post","type-post","status-publish","format-standard","hentry","category-vaccines","tag-cancer","tag-dna-damage","tag-mrna","tag-spike"],"_links":{"self":[{"href":"https:\/\/www.biblaridion.info\/blog\/wp-json\/wp\/v2\/posts\/21935","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.biblaridion.info\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.biblaridion.info\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.biblaridion.info\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.biblaridion.info\/blog\/wp-json\/wp\/v2\/comments?post=21935"}],"version-history":[{"count":5,"href":"https:\/\/www.biblaridion.info\/blog\/wp-json\/wp\/v2\/posts\/21935\/revisions"}],"predecessor-version":[{"id":21940,"href":"https:\/\/www.biblaridion.info\/blog\/wp-json\/wp\/v2\/posts\/21935\/revisions\/21940"}],"wp:attachment":[{"href":"https:\/\/www.biblaridion.info\/blog\/wp-json\/wp\/v2\/media?parent=21935"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.biblaridion.info\/blog\/wp-json\/wp\/v2\/categories?post=21935"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.biblaridion.info\/blog\/wp-json\/wp\/v2\/tags?post=21935"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}