{"id":27822,"date":"2022-04-26T14:07:45","date_gmt":"2022-04-26T14:07:45","guid":{"rendered":"https:\/\/www.biblaridion.info\/blog\/?p=27822"},"modified":"2022-04-26T14:07:45","modified_gmt":"2022-04-26T14:07:45","slug":"virus-evolution-and-lnp","status":"publish","type":"post","link":"https:\/\/www.biblaridion.info\/blog\/virus-evolution-and-lnp\/","title":{"rendered":"Virus evolution and LNP"},"content":{"rendered":"<h1>Virus evolution and LNP<\/h1>\n<p><strong>The Explosion of Cancer and Latent Disease: The Lipid Nanoparticle Platform Is Asking for Trouble (5 min)<br \/>\n<\/strong><\/p>\n<p><iframe loading=\"lazy\" class=\"wp-embedded-content\" sandbox=\"allow-scripts\" security=\"restricted\" title=\"The Explosion of Cancer and Latent Disease: The Lipid Nanoparticle Platform Is Asking for Trouble\" src=\"https:\/\/rumble.com\/embed\/vzmfs5\/?pub=4#?secret=QzA8v7P88w\" data-secret=\"QzA8v7P88w\" width=\"1920\" height=\"1080\" frameborder=\"0\"><\/iframe><\/p>\n<h2 class=\"title style-scope ytd-video-primary-info-renderer\">Virus evolution by antibodies + BA 2 Omicron &#8211; COVID-19 vaccines update 40 (17 min)<\/h2>\n<p><span class=\"style-scope yt-formatted-string\" dir=\"auto\">How does the virus evolve inside an infected person &#8211; we commence this story with a new demonstration in a vaccinated patient, and relapse to a well-documented history in COVID-19 patients, and how antibodies can be contributing to such viral evolution. This also leads us to a hypothesis as to why evolving variants might show up in wastewater prior to taking over a population. We conclude with how the BA2 variant of the Omicron is different from the BA1 variant, demonstrating continuous uninterrupted evolution of the virus.<\/span><\/p>\n<p><iframe loading=\"lazy\" title=\"Virus evolution by antibodies + BA 2 Omicron - COVID-19 vaccines update 40\" width=\"614\" height=\"345\" src=\"https:\/\/www.youtube.com\/embed\/UBHZ7il8YXg?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe><\/p>\n<p><span class=\"style-scope yt-formatted-string\" dir=\"auto\">Described content: Vaccine patient variants: <\/span><a class=\"yt-simple-endpoint style-scope yt-formatted-string\" dir=\"auto\" spellcheck=\"false\" href=\"https:\/\/www.youtube.com\/redirect?event=video_description&amp;redir_token=QUFFLUhqa1AyNXg4clF6eWE4T1pDRjAwZWZRVHhSb3lwUXxBQ3Jtc0tsRmJDOFhuX2txSm1keUZuUWtwWTExSU9TVnQ1UG8zdThMM0hFMXFieTNSN21lMVVpZjZJa2dEeEhHcDVmSVFGRHphRnF5OVBRYzBQcmZUOXJCcTg5UnRGRXEzZ1pxOTRQdkZJXzdUNF9mRURvQ0NaQQ&amp;q=https%3A%2F%2Fwww.sciencedirect.com%2Fscience%2Farticle%2Fpii%2FS1201971222001230&amp;v=UBHZ7il8YXg\" target=\"_blank\" rel=\"nofollow noopener\">https:\/\/www.sciencedirect.com\/science&#8230;<\/a><span class=\"style-scope yt-formatted-string\" dir=\"auto\"> Variants database: <\/span><a class=\"yt-simple-endpoint style-scope yt-formatted-string\" dir=\"auto\" spellcheck=\"false\" href=\"https:\/\/www.youtube.com\/redirect?event=video_description&amp;redir_token=QUFFLUhqazF6VE1vNnN1MURwNWdJT0xyekhHWDFuT2VMZ3xBQ3Jtc0ttX0gxUEVhTFNzSDBtWXpLQVZleEdFbGxHNzVKNEFwMUd3UnFyQ0V3Wm16NURSV0RfVWk3ZklTWDgtNENfR09GXzVCdFpjbXV3OFZSOWptVkctQmRDd0lYenNBWGFUWTVDVFNaTXpwT3hNdU1GQmVDZw&amp;q=https%3A%2F%2Fcov-lineages.org%2Flineage_list.html&amp;v=UBHZ7il8YXg\" target=\"_blank\" rel=\"nofollow noopener\">https:\/\/cov-lineages.org\/lineage_list&#8230;<\/a><span class=\"style-scope yt-formatted-string\" dir=\"auto\"> Innunocompromised host: <\/span><a class=\"yt-simple-endpoint style-scope yt-formatted-string\" dir=\"auto\" spellcheck=\"false\" href=\"https:\/\/www.youtube.com\/redirect?event=video_description&amp;redir_token=QUFFLUhqbHRGelpZZmZHR2Zrd1lsVG51cl9peERwd3YzQXxBQ3Jtc0trYjg1c0d0bTdMazQ3bV9JQ2NfT2N6UGdnY0E4bjQ3NXZrbGEzQ3VtR2dPTV81ZmE2WkRKUm9DQXVTSjhpX1BfeHc0bXhSR2FNd3prc1dSTTQta1JCNWNxNWFHWGFickE0NlRpaC04elliZ0s5Z3RoYw&amp;q=https%3A%2F%2Fwww.nejm.org%2Fdoi%2F10.1056%2FNEJMc2031364&amp;v=UBHZ7il8YXg\" target=\"_blank\" rel=\"nofollow noopener\">https:\/\/www.nejm.org\/doi\/10.1056\/NEJM&#8230;<\/a><span class=\"style-scope yt-formatted-string\" dir=\"auto\"> Cancer host: <\/span><a class=\"yt-simple-endpoint style-scope yt-formatted-string\" dir=\"auto\" spellcheck=\"false\" href=\"https:\/\/www.youtube.com\/redirect?event=video_description&amp;redir_token=QUFFLUhqblcxU0p2am1TYlhXWkxjSjJNb1N4aHFERUc5QXxBQ3Jtc0tsT2EyRXpLRHA0V09EdHQ3VnBvQ0VJZnBWRWs1MTZNSnZLWHduUTJuaHZsYVl4SDJBYmk5c3pudXlFcDZZS01UV0dwelRhbEc4OWJDVlNUTHB3TjM3ZjBZa3pTUUF3UmlEVnEwQ29BYk5CTlNGNXEwbw&amp;q=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0092-8674%2820%2931456-2&amp;v=UBHZ7il8YXg\" target=\"_blank\" rel=\"nofollow noopener\">https:\/\/linkinghub.elsevier.com\/retri&#8230;<\/a><span class=\"style-scope yt-formatted-string\" dir=\"auto\"> HIV host: <\/span><a class=\"yt-simple-endpoint style-scope yt-formatted-string\" dir=\"auto\" spellcheck=\"false\" href=\"https:\/\/www.youtube.com\/redirect?event=video_description&amp;redir_token=QUFFLUhqa0k5VUFVN2dIWnpFMzl4aXBJd0pwNGp5S0lLUXxBQ3Jtc0trbUlEblFBM0IxaVR4R25VYVphNHJEWXRnQXZsNmpJWEtsSnNNTGVwY0FrMVhaQzFMOE9LWTBxaTdoR19WcEZrWXpHb2JiZkdrVEprZjBmNjVLVkQ2V3NCYWw5a3dnWE8wVlc0ckxuQ2ItQnAyZG9lcw&amp;q=https%3A%2F%2Fwww.medrxiv.org%2Fcontent%2F10.1101%2F2021.06.03.21258228v1.full-text&amp;v=UBHZ7il8YXg\" target=\"_blank\" rel=\"nofollow noopener\">https:\/\/www.medrxiv.org\/content\/10.11&#8230;<\/a><span class=\"style-scope yt-formatted-string\" dir=\"auto\"> Prolonged infection variants: <\/span><a class=\"yt-simple-endpoint style-scope yt-formatted-string\" dir=\"auto\" spellcheck=\"false\" href=\"https:\/\/www.youtube.com\/redirect?event=video_description&amp;redir_token=QUFFLUhqbGc3YkZFRTNrMHU0OEpJcnFZcVA5eWJQYjBaUXxBQ3Jtc0trOHZuODVtWHNkU3FuVVJPckFoOHB3WHlBVmdmUzc4bUU2QkhFWkl2RnRvTlJHbGJiLUQ4R1FRcGFzMGxuSy03bWFwWDFBZUtreFJPa3F6MUdBT3NLRXBXd2VxWGVrM2M2WWZkcm5zY2txOWhtTnJDdw&amp;q=https%3A%2F%2Facademic.oup.com%2Fve%2Farticle%2F7%2F2%2Fveab078%2F6377925&amp;v=UBHZ7il8YXg\" target=\"_blank\" rel=\"nofollow noopener\">https:\/\/academic.oup.com\/ve\/article\/7&#8230;<\/a><span class=\"style-scope yt-formatted-string\" dir=\"auto\"> Evolution speed: <\/span><a class=\"yt-simple-endpoint style-scope yt-formatted-string\" dir=\"auto\" spellcheck=\"false\" href=\"https:\/\/www.youtube.com\/redirect?event=video_description&amp;redir_token=QUFFLUhqbDl5QmdLQmJNVHEwQzktYVd4dW9UZEE2QzBqUXxBQ3Jtc0tsZkxPWEtXYko3WFZmUi1lc29fc2dlRDE2OVdoNFVDOFVNM0dlQUJGX1VQNVNDeWF1WHlPTEpLQTY2emdRU2N5LUlpWjdzYnBUV0xOV19xam9Yck00VE9vVG03NEYzZGtvRnBtc1l0MTZxTExON1JOWQ&amp;q=https%3A%2F%2Fwww.clinicalmicrobiologyandinfection.com%2Farticle%2FS1198-743X%2820%2930440-7%2Ffulltext&amp;v=UBHZ7il8YXg\" target=\"_blank\" rel=\"nofollow noopener\">https:\/\/www.clinicalmicrobiologyandin&#8230;<\/a><span class=\"style-scope yt-formatted-string\" dir=\"auto\"> Immune escape co-evolution: <\/span><a class=\"yt-simple-endpoint style-scope yt-formatted-string\" dir=\"auto\" spellcheck=\"false\" href=\"https:\/\/www.youtube.com\/redirect?event=video_description&amp;redir_token=QUFFLUhqbGlkNFJWbEJyN3N5LTBqSkxwX0t0YjIzX0R0d3xBQ3Jtc0tscnJRR3BnSmxXeEx5Smx6UFp6TGUtYnJVcXdzcGh0M3BrZnlfZ2NsWUJhREcwUk9rWXNKSUp2UEcwR0Z0MS1XY0YwMTFJSDZHNUZ1R2p1RzcxWDNLT1I4WHRYZ2UxbW44YnZFNndyRkI4TUh0MHdpdw&amp;q=https%3A%2F%2Fwww.science.org%2Fdoi%2F10.1126%2Fscience.abg0821&amp;v=UBHZ7il8YXg\" target=\"_blank\" rel=\"nofollow noopener\">https:\/\/www.science.org\/doi\/10.1126\/s&#8230;<\/a><span class=\"style-scope yt-formatted-string\" dir=\"auto\"> Convalescent plasma host: <\/span><a class=\"yt-simple-endpoint style-scope yt-formatted-string\" dir=\"auto\" spellcheck=\"false\" href=\"https:\/\/www.youtube.com\/redirect?event=video_description&amp;redir_token=QUFFLUhqbEFLZldvTEhaVkdReDg0NlJkckpnb1IwS011UXxBQ3Jtc0ttbmRVOElwWFdJa2M1NXduZ21xLU9wTjd0RmZ3QWlTbEo2OXJLNXVmSU0yajZHWXI2UXF0QVV3aUNldUlwRFFQbFU0Q2lwTTduRGNsZGk4WWsydjE4aFYtNDJZZC1PbnRCS2xkdWVpTVpVSDRmbWc0cw&amp;q=https%3A%2F%2Fwww.nature.com%2Farticles%2Fs41586-021-03291-y&amp;v=UBHZ7il8YXg\" target=\"_blank\" rel=\"nofollow noopener\">https:\/\/www.nature.com\/articles\/s4158&#8230;<\/a><span class=\"style-scope yt-formatted-string\" dir=\"auto\"> GIT variant evolution: <\/span><a class=\"yt-simple-endpoint style-scope yt-formatted-string\" dir=\"auto\" spellcheck=\"false\" href=\"https:\/\/www.youtube.com\/redirect?event=video_description&amp;redir_token=QUFFLUhqbG4wLVZvY1BFLW4zdVY2T0Z0aGt0ZmJuUVNSQXxBQ3Jtc0ttU2tzNC11Ry1rTVdHcjR3QWRONjZ4THY3LXlTV2lQeWhkaEF4YTZOTVhkclJuYzdpUGZ5b00xZnVLd2l4NFFSZmF4a3NZbXlPeEd5bm5SclZnblp3VEU2LXpjUlpNdU5ydlB1anBfQy1CRm5wSEgxWQ&amp;q=https%3A%2F%2Fgenomemedicine.biomedcentral.com%2Farticles%2F10.1186%2Fs13073-021-00847-5&amp;v=UBHZ7il8YXg\" target=\"_blank\" rel=\"nofollow noopener\">https:\/\/genomemedicine.biomedcentral&#8230;.<\/a><span class=\"style-scope yt-formatted-string\" dir=\"auto\"> GIT viral load: <\/span><a class=\"yt-simple-endpoint style-scope yt-formatted-string\" dir=\"auto\" spellcheck=\"false\" href=\"https:\/\/www.youtube.com\/redirect?event=video_description&amp;redir_token=QUFFLUhqbDlLWWlaTnJiT183VGMwdkFjeUNwUDNoZFdCZ3xBQ3Jtc0tubzhJWFZoM1dfa2NQNndiQjFqZUFjRkkwd1FlQVFyUmo0WTlwUUxHMkppS2gzX2YySWQ0Y1htbl9raFZmWmFBMkE0WUtiMGFGTTRVWHRmQTRaZDBYdnJyQWs3bURuSWFKSGpMZ2g4dy1sa3lGZ3U1aw&amp;q=https%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FS0016-5085%2820%2930448-0%2Ffulltext&amp;v=UBHZ7il8YXg\" target=\"_blank\" rel=\"nofollow noopener\">https:\/\/www.gastrojournal.org\/article&#8230;<\/a><span class=\"style-scope yt-formatted-string\" dir=\"auto\"> Viral load impact: <\/span><a class=\"yt-simple-endpoint style-scope yt-formatted-string\" dir=\"auto\" spellcheck=\"false\" href=\"https:\/\/www.youtube.com\/redirect?event=video_description&amp;redir_token=QUFFLUhqbVJDQWpUT2lxNF9mVngxUDZXbm84OTEtcFhKQXxBQ3Jtc0trS280am8wc1RVRjQzZk1ORjJCNFBaUXl5V3JxQnpyMU9kTzdmdTFENHgwVlMzT3hEN20yUUJXZEpoY0lDaGNTYmFmUnpGSzdFOU9neTk4SDN1cG1KYzFFdmdmck9SZjIzM2MzN0VXTTdGcUpiUXJBUQ&amp;q=https%3A%2F%2Facademic.oup.com%2Fve%2Farticle%2F7%2F2%2Fveab078%2F6377925&amp;v=UBHZ7il8YXg\" target=\"_blank\" rel=\"nofollow noopener\">https:\/\/academic.oup.com\/ve\/article\/7&#8230;<\/a><span class=\"style-scope yt-formatted-string\" dir=\"auto\"> BA2 Omicron: <\/span><a class=\"yt-simple-endpoint style-scope yt-formatted-string\" dir=\"auto\" spellcheck=\"false\" href=\"https:\/\/www.youtube.com\/redirect?event=video_description&amp;redir_token=QUFFLUhqazdJdzVoNHZaNUdZbm9OVzcyQVN1b3NwRU9TQXxBQ3Jtc0ttX3BZM1dtVkxTMF9QVXJEeDBmaXpHYWhjeDBING9HTVJjcjFYeGVVeU9JeEo5bWQxZno5ZW9hajYxV2psSzZFWmg4c2I2T1NYMEM2RHdfX0JTV1FONGh6dUdQS3g1NWhEd1ctOUdmZXdHZlZiMTR2MA&amp;q=https%3A%2F%2Farxiv.org%2Fabs%2F2202.05031&amp;v=UBHZ7il8YXg\" target=\"_blank\" rel=\"nofollow noopener\">https:\/\/arxiv.org\/abs\/2202.05031<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Virus evolution and LNP The Explosion of Cancer and Latent Disease: The Lipid Nanoparticle Platform Is Asking for Trouble (5 min) Virus evolution by antibodies + BA 2 Omicron &#8211; COVID-19 vaccines update 40 (17 min) How does the virus evolve inside an infected person &#8211; we commence this story with a new demonstration in [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3458,2191],"tags":[2522,7602,3840,4366,6328,5550,4488],"class_list":["post-27822","post","type-post","status-publish","format-standard","hentry","category-covid","category-vaccines","tag-antibodies","tag-ba-2-omicron","tag-cancer","tag-immune-escape","tag-lnp","tag-p53","tag-variants"],"_links":{"self":[{"href":"https:\/\/www.biblaridion.info\/blog\/wp-json\/wp\/v2\/posts\/27822","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.biblaridion.info\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.biblaridion.info\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.biblaridion.info\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.biblaridion.info\/blog\/wp-json\/wp\/v2\/comments?post=27822"}],"version-history":[{"count":3,"href":"https:\/\/www.biblaridion.info\/blog\/wp-json\/wp\/v2\/posts\/27822\/revisions"}],"predecessor-version":[{"id":27825,"href":"https:\/\/www.biblaridion.info\/blog\/wp-json\/wp\/v2\/posts\/27822\/revisions\/27825"}],"wp:attachment":[{"href":"https:\/\/www.biblaridion.info\/blog\/wp-json\/wp\/v2\/media?parent=27822"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.biblaridion.info\/blog\/wp-json\/wp\/v2\/categories?post=27822"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.biblaridion.info\/blog\/wp-json\/wp\/v2\/tags?post=27822"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}