{"id":71862,"date":"2024-11-13T02:18:22","date_gmt":"2024-11-13T02:18:22","guid":{"rendered":"https:\/\/www.biblaridion.info\/blog\/?p=71862"},"modified":"2024-11-13T02:18:22","modified_gmt":"2024-11-13T02:18:22","slug":"jihad-science-2","status":"publish","type":"post","link":"https:\/\/www.biblaridion.info\/blog\/jihad-science-2\/","title":{"rendered":"Jihad Science"},"content":{"rendered":"

Jihad Science<\/h1>\n

This is a lab update from Dr Kevin McCairn.\u00a0 So far the progress report shows that\u00a0 none of the hamsters are demonstrating pathologies despite 100x the dose of intracardially administered vaccine.\u00a0 It is possible that the batches were degraded as they are old.\u00a0 Dr McCairn is testing out the equipment that he recently set up. The RT-quick or more exactly the RT-QuIC. Real-time quaking-induced conversion (RT-QuIC) is a highly sensitive in vitro assay that detects amyloid proteins and misfolded proteins, such as prions, in biospecimens. RT-QuIC is used to diagnose neurodegenerative diseases, including Creutzfeldt-Jakob disease (CJD), Lewy body disorders, and synucleinopathies. Endotoxins are lipopolysaccharides (LPS) that are found in the outer membrane of Gram-negative bacteria, including E. coli.<\/span><\/p>\n

Inflammation<\/strong><\/p>\n

LPS from E. coli can induce a strong inflammatory response through the MD2\/TLR4 receptor complex. This is because E. coli LPS has six acyl chains in the lipid A, which is the endotoxin that induces toxicity.\u00a0<\/span><\/p>\n

\n
\n
\n
<\/div>\n
Fibril generation<\/strong><\/div>\n<\/div>\n<\/div>\n<\/div>\n
\n
\n
Environmental exposures, including bacterial endotoxins, may cause neurons to generate distinct strains of fibrils. These strains could be transported to the central nervous system (CNS) and cause different types of pathology.\u00a0<\/span><\/p>\n
\n
\n
\n
<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n
\n
\n
\n
\n
Pathology<\/strong><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n
\n
\n
\n

LPS-induced signaling and immune dysregulation may be relevant to the pathophysiology of many chronic diseases, including neurodegenerative, metabolic, and cardiovascular diseases.\u00a0<\/span><\/p>\n

\n
\n
\n
<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

So far no detection of amyloid formation.\u00a0 This may be disheartening but progress in real science is slow and it is actually a good sign that we are not getting any sensationalist discoveries.\u00a0 It is important to establish sound methodologies and rigorous repeatable protocols that will withstand scrutiny as well as establishing the detection limits of the equipment.\u00a0 Slow and steady is the way to go.<\/p>\n

Lab Update (40 mins)<\/strong><\/h2>\n