Tag: 1918

Notification: Alaska or Antarctica?

Posted on

Notification: Alaska or Antarctica?

The article Alaska or Antarctica has now been updated.  I have now had time to read the article and digest it.  Alaska is where they found Spanish flu in 1997 which they subsequently resurrected (reconstructed) in 2005 and Antarctica is where they supposedly discovered SARS-Cov-2 in soil samples in 2019.   The Antarctica sample seems to be a case of contamination.  I am more concerned about how the resurrection of Spanish flu virus (H1N1 A) connects with SARS_CoV-2 which  is B-lineage.  influenza A virus subtype H1N1 (A/H1N1) is a subtype of Influenza A virus such as  Spanish flu, the 1977 Russian flu pandemic and the 2009 swine flu pandemic. It is an orthomyxovirus that contains the glycoproteins hemagglutinin and neuraminidase.

Sars-Cov-2 does not have hemagglutinin the coronavirus Spike protein is subjected to proteolytic cleavage by host proteases (i.e. trypsin and furin) in two sites at PCS (Polybasic furin Cleavage Site) located at the boundary between the S1 and S2 subunits (S1/S2 site) Binding of ACE2 with Spike S1 proteins allows the virus to adhere to lung epithelial cells and through a tube composed of Spike S2 proteins it injects the genetic material inside the host cell. Once the virus reaches the budding stage, the S2 domain is cleaved to release the fusion peptide.    So SARS-CoV-2 and H1N1 uses different mechanisms to cleave and penetrate the cell but I believe there is some sort of connection between these different strains and it is something that I will investigate further when I find time.

This  article has been updated.

Alaska or Antarctica?

 

It has been updated with this:

Update

See the thread behind this tweet (the info is starting to break through);