Tag: Fabry

Spike Protein Destroys Mitochondria

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Spike Protein Destroys Mitochondria

Covid is not just “a flu” as some suggest and the vaccine is not a cure it is a toxic transfection which codes for the spike protein.  This article is part of an ongoing series about mitochondria and lipids because I have a special interest as my family carries the Fabry mutation causing  Lysosomal Storage Disorders (LSD).  Fabry disease modifies mitochondrial structure in four different organs.  Fabry disease, an X-linked genetic condition, results from alpha-galactosidase deficiency and increased accumulation of glycosphingolipids in cardiovascular tissues.  The other blogs in this series can be found here:

https://www.biblaridion.info/blog/my-big-toe/

https://www.biblaridion.info/blog/lsd-and-covid-part-1/

https://www.biblaridion.info/blog/lsd-and-covid-part-2/

So this subject is of specific interest to me. At the moment my feet are fine. No sensations or numbness, no swelling, no red toes and no stabbing pains. My hypothesis is that every-time I encounter the virus it triggers the latent Fabry (I only have an 11% loading) so my strategy is to strengthen overall immune health and particularly mitochondrial health.  I just completed a 24 hour fast (without taking any supplements but drinking percolated coffee) and feel great but I need to lose more weight.  I have been taking Lipoic Acid (ALA and RLA) , CoQ10, Niacin as well as other supplements (Skullcap, D with K2 MK7, quercetin,NAC, C and Zn and the occasional melatonin etc etc). As well as that I am making and drinking my own kefir water, kombucha, kefir milk, making natto and trying to walk every day (got 2 hours in today). I am gardening and pickling my own veg and my chooks are laying eggs.  The Powers That Be have effectively pulled the pin on bio-warfare and we need to stay as healthy as possible.

Spike Protein Destroys Mitochondria (Studies)

It seems that my coffee and fasting are really doing the trick:

Caffeine and Autophagy To Reduce Fats in Liver

Lipids

One of the comments under Walters article was particularly interesting.

Both ozone and UVB (Ultra Violet B) cause lipid peroxidation – the main difference being the amount of antioxidants and ROS produced.

Reactive oxygen species (ROS) are natural byproducts of cellular oxidative metabolism and play important roles in the modulation of cell survival, cell death, differentiation, cell signaling, and inflammation-related factor production. Mitochondria are an important source of ROS (reactive oxygen species) within most mammalian cells. This ROS production contributes to mitochondrial damage in a range of pathologies and is also important in redox signalling from the organelle to the rest of the cell

“UVB irradiation induces lipid peroxidation and reduces antioxidant enzyme activities”

“Ozone causes lipid peroxidation but little antioxidant depletion”

What conditions do we have at altitude – high UVB and low oxygen – those are the environmental conditions produced by the spike protein! Why are athletes more at risk of sudden death? – because their highly metabolic cardiac cells/mitochondria are under so much stress from both the spike protein and the exercise, they release a ton of UV (biophotons) and ROS/free radicals and blow the casket (heart). And all the medications found to be effective in covid have a great capacity to absorb UV light and therefore reduce this “Stress” eg Quercetin

“Inhibition of UVA and UVB radiation-induced lipid oxidation by quercetin”

It is this primordial REDOX balance in life/nature, between UVB and Oxygen that controls the actions of an aerobic cell – evolution has simply allowed adaptation on a multicellular scale.

This is not as fanciful as we have already seen the benefit of light on metabolic health:

Light and Life

Further Research

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Fenofibrate protects lipoproteins from lipid peroxidation: synergistic interaction with alpha-tocopherol

https://pubmed.ncbi.nlm.nih.gov/10380122/

Liothyronine (T3 thyroid hormone) seems to help upregulate mitochondrial biogenesis while decreasing Reactive Oxidative Species ROS, both in patients with mtDNA mutations and normal people. Effect of thyroid hormone on mitochondrial properties and oxidative stress in cells from patients with mtDNA defects

https://journals.physiology.org/doi/full/10.1152/ajpcell.00415.2007

Lipid oxidation that is, and is not, inhibited by vitamin E: Consideration about physiological functions of vitamin E

https://pubmed.ncbi.nlm.nih.gov/34481937/
https://www.hsph.harvard.edu/nutritionsource/vitamin-e/
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Side note to self:   Get some vitamin E and eat more almonds

My Big Toe

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My Big Toe

My big Toe is a website about  the Theory Of Everything (T.O.E.)  but this article is actually about my big toe (lolz).  Well not actually, (my little toe as well) it is about the complexity of the immune system. Later on I will reference Jonathan Couey’s last video which I have managed to watch and digest (it was very good) so bear with the boorish recounting of my ailments because there is a health point to this story and you may find it helpful.

Anyone who follows this blog knows that I had trouble with my feet swelling and then with tingling and numbness (tinnitus as well but that is another story). I also had “covid toe” (red and itchy inflamed and sore). Now, there are a number of conditions that can lead to swelling of the feet. Swelling feet could be related to heart problems or the lymphatic system and numbness and pins and needles to peripheral nephropathy which can have many underlying causes.   Red toes could be chilblains or gout or…..

The problems with my feet started in the last two years and I believe that they are covid related but not entirely.  I have an 11% loading for Fabry (inherited from my mum) that is related to mitochondrial disease and  lysosomes that function in lipid processing. My hypothesis is that the virus (I am unvaccinated) which is immunogenic can trigger any latent diseases, particularly autoimmune responses.  It is unavoidable that you will come into contact with the virus especially as it exists as  quasispecies swarms in the vaccinated who are able to maintain high viral loads and shed viral exosomes (that is now a proven fact).

I have seen improvement with my feet.  I no longer have as much trouble with with stabbing pains or tingling (pins and needles) or numbness. I no longer have much trouble with swelling. Initially, I took garlic and aspirin and elevated my feet. That worked and I went to the doctor and asked for a D-dimer blood test.  There was none present?  (I was worried about micro-clotting).  I started seriously supplementing and raised my Vitamin D levels (taking about 2,000 units a day) and  quercetin, Vitamin C with Zinc, turmeric, aspirin, fish oils,NAC and many more. It seemed to help but then I started getting red inflamed toes?  Could it be a side effect of supplementing, or covid or latent Fabry?   Very difficult to disambiguate.  I went and had another blood test and they phoned me up and said that I had high calcium levels. They wanted me to call into the surgery and I did not bother but it raised alarm bells.

Dysregulation of the calcium channel at the cellular level is dangerous as it is involved in so many processes.  On top of that I began hearing that Vitamin D can leach calcium from the bones and that it is a hormone and immune suppressive.   You do not want to suppress your immune system (at least not permanently) but different studies showed that low Vitamin D levels led to higher death rates from Covid.   So what should I do?  That led to the article To D or not to D?

My research (so far) shows that the immune system and T cells in particular are hyper-activated (see Walter Chestnut et al on this), therefore it will be beneficial to damp down the immune system temporarily.  The leaching problem is solved by taking the D together with vitamin K2 (MK-7).  Moreover, I have reduced my D intake and only use it when I believe that I have been exposed (like now when the toe next to my big toe is going  red).

As far as the Fabry is concerned (which can also dysregulate calcium) I now take R-Lipoic Acid and A-Lipoic Acid together with (Flush free) Niacin and the enzyme CoQ10.  I have also taken up intermittent fasting (and am losing weight) and make sure I walk at least an hour a day.  Recently I have started taking skullcap and drinking green tea or making green tea kombucha. Also making water  Kefir and probiotic milk Kefir.   The one thing I need is more sleep but I don’t seem to have enough time (lolz).  All in all I have seen massive improvements with my feet and I am losing weight.  Also I have noticed an improvement in bowel movements (as if you wanted to know) because I had a time with constant loose stool and diarrhea which should come as no surprise considering the lung-gut-brain connection discussed in Jonathan’s previous video.

Feed back loops

The immune system and biochemistry is very complex and there are many feedback loops.  I believe that is why you get so many conflicting results when assessing different treatments. It is all about balance.  Down-regulation and up-regulation of genes. Push and pull.  Even water can kill you if you drink too much.  Everything is poisonous it is all about the dose. I am a mere bucket chemist and in my world you have a limited number of outcomes with chemical reactions and even then “unknowns” can happen. A salutatory lesson was when a reactor blew up showering people with hot sulfuric acid in what was a runaway side reaction (we didn’t know that could happen! lolz).  Now the human body is far more complex and any PhD scientist who thinks they have it all figured out is in my view a nob and suffering from a god-complex dose of hubris.  How about a bit of humility?  You think you can “correct” natures mistakes?  Perhaps you are one of natures mistakes (lolz).

The one thing I want you to take away from this article is the complexity of biological systems.  We are not mere machines and we do have an indefinable spiritual element and consciousness that transcends the constrictions of reductionist approaches. The image that Spartacus posted in Jonathan’s stream should be downloaded and inspected (and I bet that does not even cover everything). Not only do we have interactions between the virus and our body and the vaccine (transfection) and our body, but between the virus and the vaccine (transfection) itself and also between any latent disease and or substances and the virus/vaccine. The possibilities are astounding and anyone who thinks they know it all is an idiot.

Covid 19 interaction Map

In case you missed it here was Jonathan’s discussion of the Spartacus interview.  This was a first rate presentation.  Jonathan discusses vitamin D at about 38 mins:

Gigaohm Biological (15 July)

Conclusion

You are responsible for your health.  Experiment with what works and keep an eye on how  your body reacts. Tune into your own body.   I will probably go for another blood check when things settle down but I am very wary of the medical establishment at the moment.  Very few doctors stood up and did the right thing.  Unlike Johanna who took her oath seriously.

 

LSD and Covid (Part 1)

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LSD and Covid (Part 1)

This is my personal health detective story (not a story about dropping acid and psychedelic experiences while combating covid…lolz).  Although this investigation is primarily for my own benefit and that of my family it has wider implications.  LSD in this investigation stands for Lysosomal Storage Disorders.   A lysosome has three main functions: the breakdown/digestion of macromolecules (carbohydrates, lipids, proteins, and nucleic acids), cell membrane repairs, and responses against foreign substances such as bacteria, viruses and other antigens.  Now the Lysosome  and the Mitochondria (Power house of the cell)  talk to each other.  Sometimes, they tell each other jokes and swap rude stories but usually they signal different path ways that regulate many key processes such as autophagy, proliferation, and cell death.

You may have seen in a previous post (https://www.biblaridion.info/blog/herbals-and-more/) that I was having feet problems and I found out via a blood test that I had high Calcium levels and this reminded me of something that Walter Chestnut had written (but that tweet no longer exists because Walter has been suspended from Twitter but now he is on Gab). Now it turns out that calcium is critical in regulating Mitochondrial signalling.

Fabry is not Fab

So now we come back to Lysosomes and Mitochondria talking to each other and the fact that I know that I have 12% of Fabry disease.   How do I know that?   I know because I was tested years ago because my mother suffers chronic pain and fibromyositis/fibromyalgia and the endocrinologist asked if all her children could be tested because it is a rare genetic disease and they were studying it.  Apparently I have 12% (how can you have 12% of a disease?) one sister has over 40% (she is quite sick with covid at the moment) another about 30%  and another at 0%).  To be honest I forgot all about it until my feet swelled up and started hurting.  Even then it did not occur to me until I started digging (am I thick or what?) and finally the penny dropped. If you are still reading this stick with it to the end…..because this virus will find and amplify any genetic weakness you have (and so will the vaccine). Defective lysosomal storage in Fabry disease modifies mitochondrial structure, metabolism and turnover in renal epithelial cells.

People who have Fabry disease don’t have the enzymes that break down lipids or fats. These fats collect in blood vessels and tissue, raising the risk of heart attack, stroke and kidney failure. Fabry disease is caused by mutations in the GLA gene. This gene provides instructions for making an enzyme called alpha-galactosidase A.

Lysosomal disease

Walter Chestnut got kicked off Twitter for this article ASP: SPIKE PROTEIN AMYLOIDOSIS in which he states that the spike protein is inducing fatal, systemic Amyloidosis. In his table he classifies Lysozyme as an Hereditary fibril protein within the clinical setting of familial systemic amyloidosis.  Dr Kevin McCairn has been warning for two years about neurotropic disease and amyloidosis. In fact he just discussed this paper on a live stream; Accelerated biological aging in COVID-19 patients.  The disease profile is multi-faceted and we are seeing heart attacks and strokes as well as brain disease etc. There is literally something for everyone:

This review paper by Seneff et al. (2022) summarises the current literature on mRNA and its effects on the molecular biology within human cells. The findings are shocking.

👉🏻 mRNA vaccines promote sustained synthesis of the SARS-CoV-2 spike protein.

👉🏻 The spike protein is neurotoxic, and it impairs DNA repair mechanisms.

👉🏻 Suppression of type I interferon responses results in impaired innate immunity.

👉🏻 The mRNA vaccines potentially cause increased risk to infectious diseases and cancer.

👉🏻 Codon optimization results in G-rich mRNA that has unpredictable complex effects.

The authors conclude that “billions of lives are potentially at risk, given the large number of individuals injected with the […] mRNA vaccines […]. We call on the public health institutions to demonstrate, with evidence, why the issues discussed in this paper are not relevant to public health, or to acknowledge that they are and to act accordingly.”

Conclusion

Whether you caught covid or got the “vaccine” (transfection) you are bound to come down with something. Many of us may be unaware that we have a hereditary disease.  The virus will go for any systemic weak spot. And herein lies the problem, the very diversity of symptoms and diseases makes it virtually impossible to establish causality. There will be a spectrum of responses with some people immediately harmed and others facing longer term degeneration.  It is truly the work of an evil genius…but now we know.  And you cannot hide the excess deaths and the increases in all cause mortality. The truth will out.

As for me I believe that I have the type 2 “later-onset” subtype and that it was probably triggered by Covid but it looks like it was on the cards anyway.  It seems that nothing much can be done except treat the symptoms (kidney and heart failure) or the more exotic gene therapy or more accurately Enzyme replacement therapy (ERT) is the cornerstone for treatment of Fabry disease and synthetic enzyme, produced by recombinant DNA technology, is infused intravenously.  I think I will pass on that or any other interventions like transplants.  No thank you.

However, what I have learnt is that the mitochondria make a big difference in the way that the lysosome works. Outcomes can be substantially improved if you boost mitochondrial health.  In fact, mitochondrial health makes a difference in a number of diseases.  That is what we will be looking at in part 2.