Tag: adjuvant

mRNA stability

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mRNA stability

This post was inspired by the Couey vs Wilson debate which I am still transcribing and which can be found here:

Couey vs Wilson debate

The debate got rather heated and complex on the question of whether or not mRNA is an adjuvant or a self-adjuvant as their are studies that indicate that it could be used as an adjuvant.  Now, an adjuvant is a compound or chemical that irritates or triggers the immune system.

All vaccines have adjuvants and Dr Wilson (citing a scientific study) showed that mRNA could act as a self-adjuvant.    In other words there would be no need for the addition of an adjuvant.    The objection voiced by Jonathan was that mRNA is highly immunogenic. In other words it could trigger all sorts of autoimmune diseases and inflamation, especially if it was free floating in the blood.

In order to prevent this they need to do two things 1. encapsulate the mRNA in a Lipid Nano Particle (LNP)  and 2. stabilize the mRNA.  It turns out they do use PEG and polysorbate 80 as adjuvants.

 

PEG is a long chain polymer and its characteristics are different depending on the length of the polymer chain.  Polysorbate 80 is similar to PEG.   I have useed these substances as surfactants etc when making polymers. They have certain hydrophobic and hydrophilic qualities which can be used when mixing aqueous and oil phases and in micelle formation. The above paper lists MF59 adjuvant as an emulsion adjuvant composed of an oil phase (squalene 4.3%): and an aqueous phase (polysorbate 80:0.5%, sorbitan trioleate 0.5%). These vaccines do use an adjuvant, therefore Dr Wilson was incorrect.

Polyethylene glycol

A PEGylated lipid is used as an excipient in both the Moderna and Pfizer–BioNTech vaccines for SARS-CoV-2. Both RNA vaccines consist of messenger RNA, or mRNA, encased in a bubble of oily molecules called lipids. Proprietary lipid technology is used for each. In both vaccines, the bubbles are coated with a stabilizing molecule of polyethylene glycol.[medical citation needed] As of December 2020 there is some concern that PEG could trigger allergic reaction, and in fact allergic reactions are the driver for both the United Kingdom and Canadian regulators to issue an advisory, noting that: two “individuals in the U.K… were treated and have recovered” from anaphylactic shock. As of 18 December, the US CDC stated that in their jurisdiction six cases of “severe allergic reaction” had been recorded from more than 250,000 vaccinations, and of those six only one person had a “history of vaccination reactions”

Two things to mention here, firstly, many of the anaphylactic reactions are cause by the adjuvants like PEG and secondly, PEG and other polymers are being examined as delivery mechanisms for drugs because they cross the Blood Brain Barrier (BBB). If that is the case then they should also be able to deliver the spike protein across the BBB and evidence is emerging that happens.  That is not a good thing. There is a reason the brain is protected and segregated from the circulatory system and while it might be desirable to cross the BBB to treat diseases like dementia and Parkinson’s it comes with a risk.

So, as far as the debate is concerned Jonathan is correct. The vaccines do have an adjuvant and it is a LNP.  Note that the Wikipedia quote above uses the word excipient rather than adjuvant. An excipient is an inactive substance ….but is it really inactive? How can it be “inactive” when PEG antibodies are found and when some people suffer anaphylactic shock?

Polyethylene Glycol Immunogenicity: Theoretical, Clinical, and Practical Aspects of Anti-Polyethylene Glycol Antibodies

Pseudouridine

Wilson claimed that the self-adjuvant effect of mRNA was due to the pseudourodilatation of the mRNA. Pseudouridine is supposed to be more stable.

Ψ (pseudouridine) is also found in mRNAs which are the template for protein synthesis. Ψ residues in mRNA can affect the coding specificity of stop codons UAA, UGA, and UAG. In these stop codons both a U→Ψ modification and a U→C mutation both promote nonsense suppression.[6] In the SARS-CoV2 vaccine from BioNTech/Pfizer, also known as BNT162b2, Tozinameran or Comirnaty, all U's have been substituted with N1-methylpseudouridine,[7] a nucleoside related to Ψ that contains a methyl group added to N1 atom.

This is the tweet (second one Tishbite) that I sent out (well worth reading):

 

They’ve fiddled around with codon optimization to increase stability, but that translates into (1) enormous quantities produced of spike and (2) a different spike protein which could be even more pathogenic.

 

In case the above tweet disappears the link takes you here:

https://berthub.eu/articles/posts/reverse-engineering-source-code-of-the-biontech-pfizer-vaccine/

They are making people disappear off twitter (and FB)….this guy is good:

Conclusion

None of that fills me with confidence especially the fact that it can misfold.  That can lead to prions and neurodegeneration. Expect to see more diseases of the Central Nervous System,  dementia, Parkinson and CJD as well as more strokes, cancers and heart attacks. Don’t let them go anywhere near the kids with this.  We have been warning for more than a year and a half.  Is anyone listening?

Gigaohm Biological (3 Oct)

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Gigaohm Biological (3 Oct)

I just finished listening to the Live stream and I recommend it even though it is long (3 hours).   Especially the first part where Jonathan tells us about his life and his passions and why he lost his job at the University.  This is why so many academics are not speaking out.  The institutions are corrupt and captured and anyone who speaks out will never work again in academia.  So I have enormous respect for Jonathan because he has risked it all.  Standing for truth comes at a price….it always does (just ask the other J.C. lolz).

J.C. was a founding member of Drastic and he has been written out of the picture (deliberately in my view).  It looks like Drastic is now being controlled by the intelligence agencies. At 2:24 Jonathan explains that Drastic is focusing on the furin cleavage site but not all the other viral additions. Jonathan has figured out that the spike protein is its own adjuvant (An adjuvant is a substance that enhances the immune system’s response to the presence of an antigen). Jonathan expects an intense increase in cancers and i said as much myself some time back.

Gigaohm Biological (3 Oct) 2:50

 

Gigaohm Biological (27 Sept)

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Gigaohm Biological (27 Sept)

This is a terrible indictment against the establishment.  The evidence is now in and it can no longer be ignored.  They are guilty of criminal activity and malfeasance.  This video is important and J.C. has slowly been building his case. I have produced a running order for the video with all the links and also extra resource material.  Get this out everywhere.  On every platform.  Remember we are at war and they are trying to force you and harm you.  Do your bit in spreading the truth.  This is all backed up by solid science. See below for the resources – a very important tweet thread and videos.

A bunch of criminals and liars (2 hours)

0:00 Introduction.
  A crime has been committed
17:00 Geert and Robert interview by Phillip Macmillan

Vejon Health YT Channel *See below*
20:00 propaganda = no context and no shared narratives
24:00 AVRIL HAINES participated in Event 201 she has a law degree from Georgetown University Law Center and Jewish- Director of National Intelligence for the Biden administration
 
33:00 good summary
39:00 psychological operations
55:00 a call to pause
1:00 viral load the same
1:03 enrichment (mutants)
1:09 Rapid and parallel adaptive mutations in spike S1 drive clade success in SARS-CoV-2 (Trevor Bedford)
1:12 car analogy
  “Immune system have been focused so highly on S1 that they are enriching it in a way that is quantifiably unnatural. I mean I don’t know how much more scary it can get than this.  Geert Vanden Bossche probably hasn’t seen this data yet, if he did he would probably be crapping his pants”.
1:16 Unnatural Enrichment
1:20 Robust T Cell Immunity in Convalescent Individuals with Asymptomatic or Mild COVID-19
1:24 SARS-CoV-2-specific T cell immunity in cases of COVID-19 and SARS, and uninfected controls
 
  Highly functional virus-specific cellular immune response in asymptomatic SARS-CoV-2 infection
 
  Longitudinal analysis shows durable and broad

immune memory after SARS-CoV-2 infection with

persisting antibody responses and memory B and

T cells
1:25 Selective and cross-reactive SARS-CoV-2 T cell epitopes in unexposed humans
1:28 We have been lied to …..we already have Tcell protection
  SARS-CoV-2 genome-wide T cell epitope mapping reveals immunodominance and substantial CD8+ T cell activation in COVID-19 patients
1:30 Not developing epitopes to the S-protein….to the various other ones
1:33 Elevated HIV Infection of CD4 T Cells in MRKAd5 Vaccine Recipients Due to CD8 T Cells Targeting Adapted Epitopes
  Normally, LAV (Live Attenuated Vaccines) require the use of an adjuvant or a chemical irritant to stimulate or kick start the immune system and activate the Dendritic cells will pick up the attenuated virus and present pieces of it to the lymph nodes.  The SPIKE PROTEIN IS THE ADJUVANT not the LNP (Liquid Nano Particle) which is the delivery mechanism.  Small sequences (like gp120 HIV) were inserted by design into the S-protein in order to make unnecessary for it to require an adjuvant in order to be immunogenic.
1:35 ADE – Specific antibodies made only for the S-protein making the situation worse by blocking access to other proteins
1:36 list of short sequences of overlapping antigens in the S-protein (they added all sorts of shit)
  Coronavirus biology and replication: implications for SARS-CoV-2
1:38 In other words, it is THE VACCINES (TRANSFECTIONS) that upregulated for the immune proteins
  Autoantibodies against type I IFNs in patients with life-threatening COVID-19
  They are interfering with interferon
  From Anti-Severe Acute Respiratory Syndrome Coronavirus w Immune Response to Cancer Onset via Molecular Mimicry and Cross-Reactivity
  Tumour suppressor proteins are targeted making cancers more likely.
1:40 Reactivation of herpes simplex keratitis following vaccination for COVID-19
 
  spike protein binds to and changes cells in the heart
1:41 Pericytes control key neurovascular functions and neuronal phenotype in the adult brain and during brain aging
1:42 Paralysed kids
1:43 Fauci knows about ADE
1:44 Where are the animal studies for ADE?
  Vaccine-associated enhanced disease: Case definition and guidelines for data collection, analysis, and presentation of immunization safety data
1:46 Antibodies are not an indicator of immunity T cells are
1:49 Lifelong immunity to the flu
  Potent protection against h5N1 and H7n( Influenza via Childhood Hemgglutinin Imprinting
1:50 Fauci criminal
1:51 Swarm and incompetent replication
1:53 Each natural infection is a unique bottleneck. Each immunized infection is not a unique bottleneck.
  Viral quasispeccies
 

Resources

Avril Haines is Jewish and so is Rebecca Katz (who mentored Peter Hotez who is also Jewish). Both Katz and Haines went to Georgetown which seems to be a CIA finishing school.   These people are CRIMINALS.    Jane Halton from Australia was also at Event 201. She is also linked to the intelligence services.

Trust no one.   This is a global conspiracy and these are crimes against humanity.

Meeting of the COVID-19 Giants with Geert Vanden Bossche and Robert Malone MD (1:55 min)

They are saying all the right things but remember that Malone was DARPA funded and both Malone and Geert were at the vaccination conference with the CDC etc. Have they had a falling out or a change of heart?   I don’t trust anyone right now.   And Malone has started promoting Novavax.   As far as I am concerned that whole “industry” is suspect.  They have been doing GOF for  years. Many of the diseases that we have (West Nile Virus and AIDS) is because of their malfeasance.